Nicotinamide (Niacinamide) Powder CAS 98-92-0
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Description
Nicotinamide (Vitamin B3) USP/PC Grade Best Seller
INCI Name: Niacinamide | CAS: 98-92-0
Onerchem’s Nicotinamide is a high-purity, low-nicotinic acid grade Vitamin B3 designed specifically for premium cosmetic formulations. It acts as a versatile active ingredient targeting skin brightening, barrier repair, oil control, and anti-aging. Our proprietary purification process ensures < 50ppm residual nicotinic acid, minimizing the risk of skin flushing and irritation.
I. Technical Specifications (TDS Summary)
We adhere to strict quality control standards ensuring our Nicotinamide meets USP, BP, and EP pharmacopeia requirements.
| Parameter | Specification (Onerchem Standard) | Typical Analysis |
|---|---|---|
| Appearance | White Crystalline Powder | Conforms |
| Assay (HPLC) | 99.0% ~ 101.0% | 99.8% |
| Nicotinic Acid | ≤ 200 ppm (Industry Standard) | < 40 ppm (Superior) |
| pH (5% Solution) | 6.0 ~ 7.5 | 6.8 |
| Loss on Drying | ≤ 0.5% | 0.1% |
| Heavy Metals | ≤ 20 ppm | < 10 ppm |
| Microbial Count | < 100 CFU/g | < 10 CFU/g |
*Full COA and MSDS are available upon request.
II. Mechanism of Action & Key Benefits
✨ Skin Brightening
Mechanism: Inhibits the transfer of melanosomes from melanocytes to keratinocytes by 35-68%.
Result: Reduces the appearance of dark spots and hyperpigmentation without inhibiting tyrosinase activity directly, making it a safe partner for Alpha-Arbutin.
🛡️ Barrier Repair
Mechanism: Upregulates the synthesis of Ceramides, Free Fatty Acids, and Cholesterol in the stratum corneum.
Result: Reduces Transepidermal Water Loss (TEWL), strengthens the skin barrier, and improves skin tolerance to external aggressors.
⚖️ Oil Control & Pore Reduction
Mechanism: Regulates sebaceous lipid synthesis.
Result: Reduces excess sebum production and minimizes the appearance of enlarged pores, ideal for acne-prone skin formulations.
III. Formulation Guide for R&D
⚠️ Crucial Stability Warning:
Avoid formulating Nicotinamide in highly acidic environments (pH < 5.0) or high temperatures for extended periods. Under these conditions, Nicotinamide may hydrolyze into Nicotinic Acid, which causes skin vasodilation (flushing/redness).
-
Recommended Dosage:
- 2.0% - 5.0% for Whitening & Anti-aging
- 1.0% - 2.0% for Barrier Repair
- 4.0% for Acne Control (comparable efficacy to Clindamycin in studies)
- Optimal pH: Final formulation pH should be maintained between 5.5 and 7.0.
- Solubility: Highly water-soluble. Add to the water phase at temperatures below 60°C.
- Compatibility: Compatible with Peptides, Hyaluronic Acid, and Arbutin. When using with Vitamin C (L-Ascorbic Acid), formulate at different pH levels or use stable derivatives (e.g., Sodium Ascorbyl Phosphate).
IV. Frequently Asked Questions
Q: What is the difference between Nicotinamide and Niacin?
A: While both are forms of Vitamin B3, Niacin causes skin flushing due to vasodilation. Nicotinamide is the amide form, which does not cause flushing and is suitable for topical cosmetic use. Onerchem ensures strictly low residual Niacin levels.
Q: Is your Nicotinamide synthetic or natural?
A: Our Nicotinamide is produced via an advanced synthetic process to ensure high purity (99%+) and consistency, avoiding impurities often found in natural extraction. It is Vegan and Cruelty-Free.
Q: Can I use this in clear formulations?
A: Yes, Onerchem's Nicotinamide dissolves completely in water to form a clear, colorless solution, making it perfect for serums, toners, and gels.
Ready to Scale Your Production?
Whether you need a 1kg R&D sample or 500kg commercial batch, Onerchem supports your supply chain.
Package: 25kg Fiber Drum / 1kg Foil Bag
REQUEST QUOTE & SAMPLE
Formulation Support Available
This ingredient is a core component of our Whitening Application Solutions.
In-depth Technical Comparison
Alpha Arbutin vs. Niacinamide: Which one fits your formula best?
Additional information
| CAS number |
98-92-0 |
|---|---|
| IUPAC Name |
Pyridine-3-carboxamide |
| Molecular Formula |
C₆H₆N₂O |
| Molecular Weight |
122.12-122.13 g/mol |
| Physical Form |
White powder or crystals |
| Purity |
≥98.5% (HPLC, dried basis) |
| Melting Point |
128-132 °C |
| Boiling Point |
334-336 °C |
| Water Solubility |
1000-1200 g/L (20 °C) |
| pH Value |
6.0-7.5 (50 g/L in water, 20 °C) |
| Storage Condition |
Cool, dark place (<15 °C), light-sensitive |
| Safety Signal Word |
Warning (eye irritation risk) |
| Technical Group | |
| Solution | , , |
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Shipping and Delivery
Onerchem B2B
✈ Ships from China
Shipping &
Delivery
All orders ship from our facility in mainland China. Samples are dispatched within 7 working days. Bulk orders follow a confirmed production schedule — with full documentation in every parcel.
≤7
Days · Sample dispatch
15–40
Days · Bulk lead time
Global
EU · GCC · ASEAN · NA
COA
Included every shipment
Dispatch Timeline
When does my order ship?
Dispatch timelines differ between sample and bulk orders. A confirmed dispatch date is always provided at order confirmation.
Sample Orders
≤7 working days
From order confirmation to dispatch
Samples are QC-checked, weighed, and packed individually. Your COA and MSDS are printed and included in the parcel before sealing. Most sample orders ship ahead of the 7-day window.
Tracking number provided on dispatch · Express courier available on request
Bulk Orders
15–40 working days
Varies by quantity and specification
Lead time is determined by order volume, packaging format, and whether custom labelling or documentation is required. A production and dispatch schedule is confirmed in writing at the time of order.
Schedule confirmed at order · Progress updates available on request
Process
From order to delivery
Four steps from confirmed order to goods in hand.
01
Order Confirmed
Written confirmation sent within 1 business day. Dispatch schedule and freight quote included for bulk orders.
02
QC & Packing
Batch is QC-checked against HPLC data. COA and MSDS are generated and packed with the shipment.
03
Dispatch
Shipment handed to carrier. Tracking number and commercial invoice sent to buyer by email on the same day.
04
Delivery
Goods arrive at destination. 7 working-day inspection window begins from the confirmed delivery date.
Transit Times by Region
Estimated time in transit
Transit estimates run from dispatch date and exclude customs clearance time, which varies by country and commodity.
| Region | Est. Transit | Notes |
|---|---|---|
| EU & UK | 7–14 days | Import duties and VAT assessed at customs — payable by buyer. REACH compliance documentation available on request. |
| GCC / Middle East | 5–10 days | Customs clearance handled by buyer or nominated freight agent. Certificate of Origin available on request. |
| ASEAN | 4–8 days | Country-specific import licences or permits may apply for certain actives. Buyer is responsible for pre-shipment compliance checks. |
| North America | 7–14 days | FDA Prior Notice may be required for cosmetic actives. Buyers are advised to confirm import classification before ordering. |
| Other Regions | 10–20 days | Contact us to confirm shipping availability and any documentation requirements specific to your country. |
All transit times are estimates only · Delays may occur due to customs inspection, public holidays, or carrier disruption
Freight & Documentation
Costs and paperwork
Freight is quoted individually based on weight, destination, and Incoterm. Full shipping documentation is prepared for every order.
Freight Policy
—Freight cost quoted at order confirmation
—Rates based on gross weight, destination, and selected Incoterm
—Express courier (DHL / FedEx / UPS) available on request
—Sea freight available for larger bulk orders
—Import duties and local taxes are the buyer's responsibility
Documents Included
✓Commercial Invoice
✓Packing List
✓Certificate of Analysis (batch-specific)
✓MSDS / Safety Data Sheet
✓Certificate of Origin — on request
Need a freight quote or shipping advice?
Email us with your destination, estimated order weight, and preferred Incoterm — we'll respond within 1 business day.
Global shipping
EU · GCC · ASEAN · Americas
Samples ≤7 working days
From order confirmation
Full documentation
COA · MSDS · Invoice · Packing list
Tamper-evident packing
UV-protected, sealed containers
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