Panthenol
“Wholesale Pricing Available”
“Global Shipping – Technical Support Included”
Description
D-Panthenol (Provitamin B5) — The Metabolic Repair Engine
A low-molecular-weight provitamin that penetrates deep into the stratum corneum and converts enzymatically to pantothenic acid — the precursor to Coenzyme A, a cofactor in over 100 enzymatic reactions including lipid synthesis, protein acetylation, and cellular energy metabolism. Pure D-isomer form, 75% liquid concentration, cosmetic grade with HPLC ≥98% assay.
Technical Specifications
| INCI Name | Panthenol |
| Chemical Name | D-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide |
| CAS Number | 81-13-0 |
| Molecular Formula | C₉H₁₉NO₄ |
| Molecular Weight | 205.25 g/mol |
| Form | 75% clear viscous liquid |
| Isomer | Pure D-form (dexpanthenol) — biologically active isomer |
| Assay (HPLC) | ≥98.0% |
| Optical Rotation | [α]²⁰/D: +29.0° to +32.0° |
| Solubility | Freely soluble in water, ethanol, propylene glycol, glycerol |
| pH Stability | 4.0–8.5 (optimal 5.0–7.0) |
| Effective Concentration | 0.5–5.0% (hair care: up to 2%; skin care: 1–5%) |
| Process Phase | Cool-down phase preferred (avoid prolonged exposure >80°C) |
| Storage | Sealed, protected from light, 15–25°C |
| Shelf Life | 24 months (unopened, recommended storage) |
| Documentation | Batch-specific COA + MSDS + TDS included with every order |
Why D-Panthenol, not DL-Panthenol? Only the D-isomer is enzymatically converted to pantothenic acid in skin cells. DL-Panthenol (racemic mixture, available as powder) contains 50% inactive L-isomer — meaning you need twice the concentration to achieve the same biological activity. Our 75% D-Panthenol liquid delivers the pure active form with no wasted isomer content. For detailed mechanism and clinical data, see the D-Panthenol Technical Guide.
Key Properties
Deep Penetration
Low MW (205 Da) enables rapid stratum corneum penetration. Converts to pantothenic acid intracellularly, driving CoA-dependent lipid biosynthesis and barrier repair from within.
Dual Hydration
Functions as both humectant (water-binding) and emollient (skin-smoothing). Inhibits transepidermal water loss at concentrations ≥1%, clinically validated for sustained moisture retention.
Wound Healing
Accelerates keratinocyte proliferation by 15–30%. Enhances filaggrin and loricrin expression — key proteins for barrier maturation. Published evidence for post-procedure recovery.
Formulation Applications
D-Panthenol is a cold-process-friendly ingredient — simply add to the water phase at cool-down (<40°C) and stir until homogeneous. No special solubilisation required. Compatible with virtually all emulsion types, clear aqueous systems, gels, sprays, and anhydrous formulations when dissolved in a suitable co-solvent.
Skin Care
Barrier repair creams and lotions (1–5%), post-procedure recovery serums, sensitive skin formulations, after-sun care, anti-redness treatments. The anti-inflammatory and barrier-restoring properties make D-Panthenol a cornerstone of reactive skin protocols alongside Ceramide NP and Squalane.
Hair Care
Shampoos, conditioners, leave-in treatments (0.5–2%). Penetrates the hair cortex, improving elasticity, reducing split ends, and providing lasting moisture. Particularly effective in colour-treated or heat-damaged hair formulations.
Baby Care & Sensitive Skin
Nappy creams, baby lotions, atopic dermatitis support formulations. Excellent safety profile — no known sensitisation, no EU/US regulatory restrictions at standard cosmetic concentrations.
Ingredient Compatibility
Ceramide NP + Squalane — The gold-standard barrier repair stack. D-Panthenol provides the metabolic repair engine while ceramides restore lipid architecture and squalane seals the surface. See the Barrier Synergy Blueprint.
Sodium Hyaluronate — Complementary hydration at different skin depths. HA binds surface water; D-Panthenol penetrates deeper and reduces TEWL from within. No interaction concerns.
Ectoine — D-Panthenol repairs at the metabolic level; Ectoine protects at the cellular level via preferential hydration. Together they address both repair and prevention in stressed skin.
Niacinamide — Both strengthen barrier function through different pathways (CoA-driven lipid synthesis vs. ceramide biosynthesis stimulation). Fully compatible at all standard concentrations.
All peptides (Matrixyl 3000, GHK-Cu, AH-8) — No interaction. Add peptides and D-Panthenol together in the cool-down phase for optimal stability.
Strong acids (AHA/BHA at pH <3.5) — D-Panthenol is stable across pH 4.0–8.5 but may show reduced conversion efficiency below pH 4.0. In acid-heavy formulations, verify final pH remains above 4.0 or add D-Panthenol to a separate product step.
Prolonged heat (>80°C) — Extended heating can cause slight yellowing and partial racemisation (D→DL conversion), reducing biological activity. Always add at cool-down when possible.
Quality Assurance & Documentation
Every batch of D-Panthenol ships with full documentation: Certificate of Analysis (COA) with HPLC assay, optical rotation, residual solvents, heavy metals, and microbial limits; Material Safety Data Sheet (MSDS); and Technical Data Sheet (TDS). Need help reading a COA? See our guide: How to Read a Cosmetic Ingredient COA.
COA Verification Tip: When evaluating D-Panthenol from any supplier, check optical rotation on the COA — genuine D-Panthenol should show [α]²⁰/D between +29.0° and +32.0°. Values outside this range indicate contamination with L-isomer or DL-racemic material, which halves the effective activity per unit weight.
Batch-specific COA, MSDS, and technical support included with every order. Sample quantities available for formulation testing.
Request D-Panthenol Sample →Formulation Support Available
This ingredient is a core component of our Whitening Application Solutions.
In-depth Technical Comparison
Alpha Arbutin vs. Niacinamide: Which one fits your formula best?
Additional information
| Technical Group | |
|---|---|
| Solution | , , |
| Technical Keywords |
Provitamin B5 ,Anti-inflammatory ,Healing |
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Shipping and Delivery
Onerchem B2B
✈ Ships from China
Shipping &
Delivery
All orders ship from our facility in mainland China. Samples are dispatched within 7 working days. Bulk orders follow a confirmed production schedule — with full documentation in every parcel.
≤7
Days · Sample dispatch
15–40
Days · Bulk lead time
Global
EU · GCC · ASEAN · NA
COA
Included every shipment
Dispatch Timeline
When does my order ship?
Dispatch timelines differ between sample and bulk orders. A confirmed dispatch date is always provided at order confirmation.
Sample Orders
≤7 working days
From order confirmation to dispatch
Samples are QC-checked, weighed, and packed individually. Your COA and MSDS are printed and included in the parcel before sealing. Most sample orders ship ahead of the 7-day window.
Tracking number provided on dispatch · Express courier available on request
Bulk Orders
15–40 working days
Varies by quantity and specification
Lead time is determined by order volume, packaging format, and whether custom labelling or documentation is required. A production and dispatch schedule is confirmed in writing at the time of order.
Schedule confirmed at order · Progress updates available on request
Process
From order to delivery
Four steps from confirmed order to goods in hand.
01
Order Confirmed
Written confirmation sent within 1 business day. Dispatch schedule and freight quote included for bulk orders.
02
QC & Packing
Batch is QC-checked against HPLC data. COA and MSDS are generated and packed with the shipment.
03
Dispatch
Shipment handed to carrier. Tracking number and commercial invoice sent to buyer by email on the same day.
04
Delivery
Goods arrive at destination. 7 working-day inspection window begins from the confirmed delivery date.
Transit Times by Region
Estimated time in transit
Transit estimates run from dispatch date and exclude customs clearance time, which varies by country and commodity.
| Region | Est. Transit | Notes |
|---|---|---|
| EU & UK | 7–14 days | Import duties and VAT assessed at customs — payable by buyer. REACH compliance documentation available on request. |
| GCC / Middle East | 5–10 days | Customs clearance handled by buyer or nominated freight agent. Certificate of Origin available on request. |
| ASEAN | 4–8 days | Country-specific import licences or permits may apply for certain actives. Buyer is responsible for pre-shipment compliance checks. |
| North America | 7–14 days | FDA Prior Notice may be required for cosmetic actives. Buyers are advised to confirm import classification before ordering. |
| Other Regions | 10–20 days | Contact us to confirm shipping availability and any documentation requirements specific to your country. |
All transit times are estimates only · Delays may occur due to customs inspection, public holidays, or carrier disruption
Freight & Documentation
Costs and paperwork
Freight is quoted individually based on weight, destination, and Incoterm. Full shipping documentation is prepared for every order.
Freight Policy
—Freight cost quoted at order confirmation
—Rates based on gross weight, destination, and selected Incoterm
—Express courier (DHL / FedEx / UPS) available on request
—Sea freight available for larger bulk orders
—Import duties and local taxes are the buyer's responsibility
Documents Included
✓Commercial Invoice
✓Packing List
✓Certificate of Analysis (batch-specific)
✓MSDS / Safety Data Sheet
✓Certificate of Origin — on request
Need a freight quote or shipping advice?
Email us with your destination, estimated order weight, and preferred Incoterm — we'll respond within 1 business day.
Global shipping
EU · GCC · ASEAN · Americas
Samples ≤7 working days
From order confirmation
Full documentation
COA · MSDS · Invoice · Packing list
Tamper-evident packing
UV-protected, sealed containers
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