Ectoine Powder (CAS 96702-03-3) – 99% Purity
Onerchem offers premium Ectoine (99% HPLC), a bio-fermented extremolyte. It provides superior skin barrier repair, long-term hydration, and protection against UV/Blue-light induced cellular stress. Ideal for medical-grade and anti-pollution skincare.
“Wholesale Pricing Available”
“Global Shipping – Technical Support Included”
Description
Extremolyte · Barrier Repair · Microbiome-Friendly
Ectoine
CAS 96702-03-3 · (S)-2-Methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid
≥99%
HPLC Purity
Recommended Dose
0.5 – 2.0%
1% standard for sensitive skin
Optimal pH
4.0 – 8.0
Exceptionally broad — highly stable
Solubility
Water soluble
Aqueous phase — easy incorporation
Heat Stability
Stable to 120°C
Can go into Phase A directly
Why Ectoine
1
Nature's most effective cell protector — evolved under extreme stress
Ectoine is a natural extremolyte produced by bacteria living in salt lakes, hot springs, and desert environments where desiccation, UV radiation, and temperature extremes would destroy ordinary cells. These bacteria accumulate ectoine to create a protective water shell around their proteins and membranes. Topically applied, this same mechanism protects skin cells from osmotic stress, UV damage, and the inflammatory triggers that accelerate visible aging.
2
Stabilises the skin microbiome — a differentiated mechanism most actives miss
Ectoine has demonstrated ability to support the survival of beneficial skin bacteria (particularly Staphylococcus epidermidis) under stress conditions, while reducing the inflammatory response to dysbiosis triggers. As microbiome skincare becomes mainstream, ectoine's prebiotic-like protective mechanism gives it a scientifically credible positioning that goes beyond standard barrier actives — and that resonates with dermatologists and informed consumers alike.
3
Formulation-friendly in a way that few premium actives are
Stable from pH 4 to 8 and up to 120°C, water-soluble, colourless, odourless, and compatible with essentially every other cosmetic active. Ectoine imposes no constraints on formula architecture — it simply goes into the water phase and gets on with protecting cells. For a premium-positioned active, this ease of incorporation is exceptional and a genuine selling point to formulators who have struggled with more demanding actives.
How Ectoine Works
Mechanism of Action · Extremolyte
Cellular protection at three levels simultaneously
Level 1
Preferential Hydration
Ectoine molecules form a structured hydration shell around proteins, enzymes, and cell membranes — a phenomenon called "preferential exclusion." This shell maintains the native conformation of biological structures under osmotic stress, UV exposure, and temperature extremes. It is the same mechanism that allowed extremophilic bacteria to survive conditions that would denature normal cell components.
Level 2
Membrane Stabilisation
Ectoine interacts directly with phospholipid bilayers, increasing membrane fluidity and resistance to disruption. In practical terms, this means skin cell membranes are better able to maintain their structural integrity under inflammatory challenge, UV-induced lipid peroxidation, and the physical stresses of daily environmental exposure — reducing TEWL and supporting barrier function from the cellular level up.
Level 3
Anti-Inflammatory Signalling
Ectoine reduces the activation of pro-inflammatory cytokines — including IL-1β and TNF-α — in response to environmental triggers. This anti-inflammatory activity at the cellular signalling level complements its physical membrane stabilisation, making it active against both the acute irritation response and the chronic low-level inflammation that drives sensitive skin conditions and accelerates aging.
Formulation Parameters
Key Parameters
Dosage range0.5% – 2.0%
Optimal pH4.0 – 8.0 (very broad)
SolubilityWater soluble
Heat stabilityStable to 120°C
AppearanceWhite crystalline powder
HPLC purity≥ 99% · Batch certified
Formulation Advantages
pH flexibilityWorks in serums AND creams
Addition phaseWater phase at any temperature
Colour / odourColourless, odourless
IncompatibilitiesNone known
Skin feelNo impact — fully invisible
Trend statusGrowing · microbiome era
Ingredient Compatibility
✓ Synergistic
✓Ceramide NP, Panthenol, Squalane — Ectoine's cellular protection complements the structural barrier repair of ceramides; together they address barrier failure at cellular and lipid levels simultaneously
✓Sodium Hyaluronate — Ectoine's preferential hydration mechanism is synergistic with HA's surface hydration; combined formula addresses moisture at multiple skin depths
✓Niacinamide — Complementary anti-inflammatory pathways; both are well-tolerated on reactive skin at standard concentrations
✓ Fully Compatible
✓All peptides (Matrixyl 3000, GHK-Cu, AHP-8) — No interaction; ectoine's neutral chemistry and broad pH tolerance make it compatible with every common peptide active
✓All brightening actives (TXA, Alpha-Arbutin, 3-O-EAA) — Ectoine's anti-inflammatory activity supports brightening by reducing the inflammatory triggers that drive PIH
✓Retinol (same or separate formula) — Ectoine's membrane stabilisation and anti-inflammatory activity helps manage the retinization period — one of the strongest practical arguments for including it alongside retinol
Target Applications
Sensitive Skin Collections
Cellular membrane stabilisation and anti-inflammatory activity with zero irritation risk. The cleanest active available for rosacea, reactive, and eczema-prone skin formulas.
Microbiome Skincare
Supports survival of beneficial skin bacteria under stress. Scientifically credible positioning in the prebiotic/microbiome category — one of the fastest-growing segments in premium skincare.
Anti-Pollution Formulas
Cellular protection against particulate matter-induced oxidative and inflammatory stress. Credible science for urban skincare positioned against environmental aging.
Retinol Support Products
Ectoine in a retinol formula — or paired AM product — helps manage the retinization period by stabilising cell membranes and reducing inflammatory signalling during adaptation.
After-Sun & Recovery
Cellular protection from UV-induced membrane damage and inflammatory cascade. Natural fit for after-sun recovery formulas targeting the 24–48h post-exposure window.
Baby & Paediatric Care
Exceptional safety and tolerability profile makes ectoine one of the very few premium actives suitable for baby skincare and paediatric formulas requiring both efficacy and zero irritation risk.
Supplier Information · Onerchem
Sourcing Ectoine from Onerchem
Every batch HPLC-verified to ≥99% purity. Batch-specific COA and MSDS issued with each order. Custom pack sizes available — contact us for MOQ and current lead time.
Supply Details
Pack sizeCustom — as required
MOQContact for quote
SampleYes · 5 g available
Lead timeContact for current schedule
Quality & Documentation
Purity≥ 99% HPLC verified
COABatch-specific, every order
MSDSAvailable on request
Pre-order COAAvailable — email request
Storage & Logistics
StorageCool, dry — standard conditions
Shelf life24 months sealed
Ships fromMainland China
MarketsEU · GCC · ASEAN · North America
HPLC Purity ≥99%
Batch-Specific COA
EU Cosmetics Compliant
REACH Documentation
GCC / ASEAN Compatible
7-Day Inspection Window
Response within 1 business day
Pre-order COA available
Custom pack sizes
7-day quality inspection window
Replacement or full refund
Frequently Asked Questions
Reviews (0)
Shipping and Delivery
Onerchem B2B
✈ Ships from China
Shipping &
Delivery
All orders ship from our facility in mainland China. Samples are dispatched within 7 working days. Bulk orders follow a confirmed production schedule — with full documentation in every parcel.
≤7
Days · Sample dispatch
15–40
Days · Bulk lead time
Global
EU · GCC · ASEAN · NA
COA
Included every shipment
Dispatch Timeline
When does my order ship?
Dispatch timelines differ between sample and bulk orders. A confirmed dispatch date is always provided at order confirmation.
Sample Orders
≤7 working days
From order confirmation to dispatch
Samples are QC-checked, weighed, and packed individually. Your COA and MSDS are printed and included in the parcel before sealing. Most sample orders ship ahead of the 7-day window.
Tracking number provided on dispatch · Express courier available on request
Bulk Orders
15–40 working days
Varies by quantity and specification
Lead time is determined by order volume, packaging format, and whether custom labelling or documentation is required. A production and dispatch schedule is confirmed in writing at the time of order.
Schedule confirmed at order · Progress updates available on request
Process
From order to delivery
Four steps from confirmed order to goods in hand.
01
Order Confirmed
Written confirmation sent within 1 business day. Dispatch schedule and freight quote included for bulk orders.
02
QC & Packing
Batch is QC-checked against HPLC data. COA and MSDS are generated and packed with the shipment.
03
Dispatch
Shipment handed to carrier. Tracking number and commercial invoice sent to buyer by email on the same day.
04
Delivery
Goods arrive at destination. 7 working-day inspection window begins from the confirmed delivery date.
Transit Times by Region
Estimated time in transit
Transit estimates run from dispatch date and exclude customs clearance time, which varies by country and commodity.
| Region | Est. Transit | Notes |
|---|---|---|
| EU & UK | 7–14 days | Import duties and VAT assessed at customs — payable by buyer. REACH compliance documentation available on request. |
| GCC / Middle East | 5–10 days | Customs clearance handled by buyer or nominated freight agent. Certificate of Origin available on request. |
| ASEAN | 4–8 days | Country-specific import licences or permits may apply for certain actives. Buyer is responsible for pre-shipment compliance checks. |
| North America | 7–14 days | FDA Prior Notice may be required for cosmetic actives. Buyers are advised to confirm import classification before ordering. |
| Other Regions | 10–20 days | Contact us to confirm shipping availability and any documentation requirements specific to your country. |
All transit times are estimates only · Delays may occur due to customs inspection, public holidays, or carrier disruption
Freight & Documentation
Costs and paperwork
Freight is quoted individually based on weight, destination, and Incoterm. Full shipping documentation is prepared for every order.
Freight Policy
—Freight cost quoted at order confirmation
—Rates based on gross weight, destination, and selected Incoterm
—Express courier (DHL / FedEx / UPS) available on request
—Sea freight available for larger bulk orders
—Import duties and local taxes are the buyer's responsibility
Documents Included
✓Commercial Invoice
✓Packing List
✓Certificate of Analysis (batch-specific)
✓MSDS / Safety Data Sheet
✓Certificate of Origin — on request
Need a freight quote or shipping advice?
Email us with your destination, estimated order weight, and preferred Incoterm — we'll respond within 1 business day.
Global shipping
EU · GCC · ASEAN · Americas
Samples ≤7 working days
From order confirmation
Full documentation
COA · MSDS · Invoice · Packing list
Tamper-evident packing
UV-protected, sealed containers
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