Coenzyme Q10 | CAS 303-98-0 | Ubiquinone Skin Care | Onerchem
Buy high-purity Coenzyme Q10 (Ubiquinone) CAS 303-98-0 from Onerchem. Essential cellular energy booster and potent antioxidant for premium anti-aging formulations.
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Description
Antioxidant · Mitochondrial Energiser · Anti-Aging
Coenzyme Q10
CAS 303-98-0 · Ubiquinone · CoQ10
≥98%
HPLC Purity
Recommended Dose
0.3 – 1.0%
0.5% is the standard efficacy level
Optimal pH
4.0 – 7.0
Broad tolerance — pH stable
Solubility
Oil phase only
Lipophilic — requires emulsification
Addition Phase
Oil phase 60–70°C
Melt fully before emulsification
Why Coenzyme Q10
1
Addresses cellular energy decline — the root of aged skin
Skin CoQ10 levels decline measurably with age, beginning in the mid-30s. This decline reduces the mitochondrial ATP production that powers every cellular repair and renewal process — including collagen synthesis, barrier maintenance, and keratinocyte differentiation. Topical CoQ10 supplementation replenishes this depleted pool and supports the energy substrate fibroblasts need to function optimally.
2
Potent lipophilic antioxidant in the membrane layer
CoQ10's primary antioxidant site is the mitochondrial and cell membrane — the lipid-rich environment where most UV and pollution-driven oxidative damage originates. Its lipophilicity allows it to intercept reactive oxygen species at the membrane level, where water-soluble antioxidants like Vitamin C cannot reach. This makes CoQ10 genuinely complementary to, rather than redundant with, aqueous antioxidants.
3
Reduces expression lines via energy-dependent repair
Clinical studies show CoQ10 application reduces the depth of eye contour wrinkles — an effect attributed to both its antioxidant protection and the improved cellular energy availability that supports collagen and elastin maintenance. Unlike neurotransmitter-inhibiting peptides, this is a structural improvement, not a temporary softening effect.
How CoQ10 Works in Skin
Mechanism of Action
Three parallel pathways — energy, antioxidant, and structural
Pathway 1
Mitochondrial Energy Support
CoQ10 is an essential electron carrier in the mitochondrial electron transport chain. By replenishing depleted CoQ10 in aged skin cells, topical application supports ATP synthesis — restoring the energy currency that powers collagen synthesis, barrier maintenance, and DNA repair.
Pathway 2
Membrane Antioxidant Defence
As a lipophilic antioxidant, CoQ10 quenches free radicals directly within cell membranes — protecting membrane lipids from peroxidation, maintaining membrane fluidity, and preventing the cascade of oxidative damage that impairs cellular signalling and accelerates visible aging.
Pathway 3
Collagen & Elastin Protection
CoQ10 inhibits the expression of collagenase (MMP-1) triggered by UV exposure — reducing the enzymatic degradation of existing collagen fibres. This MMP-inhibiting effect, combined with improved cellular energy for new collagen synthesis, produces a measurable reduction in wrinkle depth with consistent use.
Formulation Parameters
Key Parameters
Dosage range0.3% – 1.0%
Optimal pH4.0 – 7.0
SolubilityOil phase only (lipophilic)
Addition phaseOil phase at 60–70°C
AppearanceBright yellow to orange powder
HPLC purity≥ 98% · Batch certified
Formulation Notes
IncorporationMelt into oil phase at 60–70°C
Colour impactYellow tint above 0.5% — plan packaging
Emulsifier req.Standard O/W or W/O system
Light sensitivityModerate — use opaque packaging
Aqueous dispersionUse solubiliser (PEG-40 HCO) at 4:1
Shelf life impactStable — antioxidant nature helps formula
Ingredient Compatibility
✓ Synergistic
✓Ferulic Acid + Tocopherol — Lipophilic antioxidant layering; complementary mechanisms across membrane and aqueous phases
✓3-O-EAA, AA2G — CoQ10 adds lipid-phase protection to VC's aqueous-phase antioxidant activity
✓Squalane, plant esters — CoQ10 disperses evenly in these emollients; ideal carrier oils
✓Ceramide NP, Panthenol — Full barrier and energy support stack; no interaction
✓ Compatible
✓Matrixyl 3000, Acetyl Hexapeptide-8 — Add peptides in cool-down phase; CoQ10 stays in oil phase
✓Niacinamide, Ergothioneine — Multi-antioxidant formula architecture; broad skin type tolerance
⚠ Note
⚠High-pH aqueous systems (> 7.5) — CoQ10 can show colour instability in highly alkaline conditions; target pH 4–7
⚠Colour management — CoQ10's yellow colour at higher concentrations may affect formula aesthetics; plan tinted or opaque packaging
Target Applications
Anti-Aging Eye Creams
Published clinical evidence for wrinkle reduction at the eye contour. The thin periorbital skin is particularly susceptible to CoQ10 depletion and oxidative aging.
Premium Anti-Aging Serums
CoQ10 at 0.3–0.5% adds a scientifically credible anti-aging mechanism to serums alongside peptides — energy support and antioxidant defence that peptides alone do not provide.
Antioxidant Moisturisers
Pairs naturally with Ferulic Acid, Vitamin E, and Vitamin C derivatives for a complete multi-phase antioxidant defence — addressing both membrane and aqueous oxidative stress.
Mature Skin Collections
Age-targeted positioning: CoQ10 depletion correlates with chronological aging, making it a clinically credible active for mature skin formulas with cellular renewal claims.
Scalp & Hair Care
CoQ10 supports scalp cell energy metabolism and protects follicle cells from oxidative stress — a growing application in premium anti-hair loss and scalp vitality products.
After-Sun & Recovery
Replenishes UV-depleted CoQ10 in sun-exposed skin. Effective in after-sun formulas targeting oxidative recovery alongside barrier-soothing actives.
Supplier Information · Onerchem
Sourcing Coenzyme Q10 from Onerchem
Every batch HPLC-verified to ≥98% purity. Batch-specific COA and MSDS issued with each order. Custom pack sizes available — contact us for MOQ and current lead time.
Supply Details
Pack sizeCustom — as required
MOQContact for quote
SampleYes · 5 g available
Lead timeContact for current schedule
Quality & Documentation
Purity≥ 98% HPLC verified
COABatch-specific, every order
MSDSAvailable on request
Pre-order COAAvailable — email request
Storage & Logistics
StorageCool, dry, away from light
Shelf life24 months sealed
Ships fromMainland China
MarketsEU · GCC · ASEAN · North America
HPLC Purity ≥98%
Batch-Specific COA
EU Cosmetics Compliant
REACH Documentation
GCC / ASEAN Compatible
7-Day Inspection Window
Response within 1 business day
Pre-order COA available
Custom pack sizes
7-day quality inspection window
Replacement or full refund
Technical FAQ
Additional information
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Shipping and Delivery
Onerchem B2B
✈ Ships from China
Shipping &
Delivery
All orders ship from our facility in mainland China. Samples are dispatched within 7 working days. Bulk orders follow a confirmed production schedule — with full documentation in every parcel.
≤7
Days · Sample dispatch
15–40
Days · Bulk lead time
Global
EU · GCC · ASEAN · NA
COA
Included every shipment
Dispatch Timeline
When does my order ship?
Dispatch timelines differ between sample and bulk orders. A confirmed dispatch date is always provided at order confirmation.
Sample Orders
≤7 working days
From order confirmation to dispatch
Samples are QC-checked, weighed, and packed individually. Your COA and MSDS are printed and included in the parcel before sealing. Most sample orders ship ahead of the 7-day window.
Tracking number provided on dispatch · Express courier available on request
Bulk Orders
15–40 working days
Varies by quantity and specification
Lead time is determined by order volume, packaging format, and whether custom labelling or documentation is required. A production and dispatch schedule is confirmed in writing at the time of order.
Schedule confirmed at order · Progress updates available on request
Process
From order to delivery
Four steps from confirmed order to goods in hand.
01
Order Confirmed
Written confirmation sent within 1 business day. Dispatch schedule and freight quote included for bulk orders.
02
QC & Packing
Batch is QC-checked against HPLC data. COA and MSDS are generated and packed with the shipment.
03
Dispatch
Shipment handed to carrier. Tracking number and commercial invoice sent to buyer by email on the same day.
04
Delivery
Goods arrive at destination. 7 working-day inspection window begins from the confirmed delivery date.
Transit Times by Region
Estimated time in transit
Transit estimates run from dispatch date and exclude customs clearance time, which varies by country and commodity.
| Region | Est. Transit | Notes |
|---|---|---|
| EU & UK | 7–14 days | Import duties and VAT assessed at customs — payable by buyer. REACH compliance documentation available on request. |
| GCC / Middle East | 5–10 days | Customs clearance handled by buyer or nominated freight agent. Certificate of Origin available on request. |
| ASEAN | 4–8 days | Country-specific import licences or permits may apply for certain actives. Buyer is responsible for pre-shipment compliance checks. |
| North America | 7–14 days | FDA Prior Notice may be required for cosmetic actives. Buyers are advised to confirm import classification before ordering. |
| Other Regions | 10–20 days | Contact us to confirm shipping availability and any documentation requirements specific to your country. |
All transit times are estimates only · Delays may occur due to customs inspection, public holidays, or carrier disruption
Freight & Documentation
Costs and paperwork
Freight is quoted individually based on weight, destination, and Incoterm. Full shipping documentation is prepared for every order.
Freight Policy
—Freight cost quoted at order confirmation
—Rates based on gross weight, destination, and selected Incoterm
—Express courier (DHL / FedEx / UPS) available on request
—Sea freight available for larger bulk orders
—Import duties and local taxes are the buyer's responsibility
Documents Included
✓Commercial Invoice
✓Packing List
✓Certificate of Analysis (batch-specific)
✓MSDS / Safety Data Sheet
✓Certificate of Origin — on request
Need a freight quote or shipping advice?
Email us with your destination, estimated order weight, and preferred Incoterm — we'll respond within 1 business day.
Global shipping
EU · GCC · ASEAN · Americas
Samples ≤7 working days
From order confirmation
Full documentation
COA · MSDS · Invoice · Packing list
Tamper-evident packing
UV-protected, sealed containers
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