Ceramides
“Wholesale Pricing Available”
“Global Shipping – Technical Support Included”
Description
Ceramide NP (Ceramide 3)
Bio-Identical Barrier Reconstruction for Medical-Grade Skincare.
🛡️ Skin Barrier Architect
Mimics the skin's natural lipid structure to repair the "brick and mortar" barrier, providing instant relief for sensitized skin.
💧 Moisture Sealant
Drastically reduces Transepidermal Water Loss (TEWL) by creating a protective, breathable film on the stratum corneum.
🔬 High Purity (98%+)
Onerchem Ceramide NP is a highly purified crystalline lipid, ensuring excellent safety profiles for hypoallergenic formulations.
Technical Matrix
| Parameter | Onerchem Standard | Analytical Method |
|---|---|---|
| Purity (HPLC) | ≥ 98.0% | Internal HPLC-FID |
| Appearance | White to Off-white Powder | Visual Inspection |
| Melting Point | 90.0°C - 105.0°C | Capillary Method |
| Loss on Drying | ≤ 2.0% | Vacuum Oven |
| Heavy Metals (Pb) | ≤ 10 ppm | ICP-MS |
Formulator's Guide to Ceramide NP
Ceramide NP is a high-melting-point lipid. For optimal efficacy, incorporate it into the oil phase and heat to 85°C - 90°C until fully transparent before emulsification.
Recommended Dosage: 0.05% - 1.0%
Synergy Tip: To achieve a "true barrier repair" effect, we suggest formulating with a 3:1:1 molar ratio of Ceramides, Cholesterol, and Fatty Acids.
“Want to master the formulation of Ceramide NP? Read our latest technical guide on solubility and synergy.”
Formulator's Technical Reference — Onerchem R&D · Ceramide NP
Oil Phase Only
✓ Barrier Science Series
Formulation Phase Guide — Where & How to Add Ceramide NP
Ceramide NP is lipid-soluble. Incorrect phase addition is the most common cause of incorporation failure.
⚠ Oil Phase Required
A
Water Phase
Aqueous base
Deionised water, humectants (glycerin, butylene glycol), water-soluble actives (HA, Niacinamide, TXA). Ceramide NP is not added here.
🌡 60–75°C
B
← Add here · Oil Phase
Ceramide NP goes in Phase B
Melt Ceramide NP into the oil phase with emollients (Squalane, esters) and emulsifiers at 70–75°C. Ensure complete dissolution before emulsification.
🌡 70–75°C
C
Emulsification
Combine A into B
Slowly add water phase to oil phase under homogenisation. Ceramide NP disperses evenly within the emulsifier network. Maintain 60–70°C during mixing.
🌡 60–70°C
D
Cool-down
Add heat-sensitive actives
Below 40°C: add peptides, fragrance, preservatives, pH-sensitive actives. Verify final emulsion pH at 5.0–6.5 for optimal skin compatibility.
✓ < 40°C
Barrier Science Series · Synergy Ecosystem
Ceramide NP anchors the complete barrier repair stack
Onerchem's four barrier actives address distinct repair mechanisms. Combined, they restore lipid bilayer integrity, reduce TEWL, and support long-term skin resilience.
⭐ Core Active
Ceramide NP
Rebuilds the lipid lamellar structure between corneocytes. Primary TEWL barrier. Restores skin's natural ceramide-to-cholesterol-to-fatty acid ratio.
0.1% – 1.0% dose
Synergy
Squalane
Lightweight emollient that mimics sebum. Helps Ceramide NP integrate into the intercellular lipid matrix without occlusion.
2–6% dose
Synergy
Sodium Hyaluronate
Fills the aqueous compartment while Ceramide repairs the lipid layer. Dual-action: surface hydration + deep reservoir fill.
0.1–0.2% dose
Synergy
D-Panthenol
Pro-vitamin B5 that activates keratinocyte differentiation. Accelerates barrier recovery and reduces inflammation during repair.
0.5–2% dose
Ingredient Compatibility
pH 5.0 – 6.5
✓ Compatible
✓
Squalane, Shea Butter, plant esters — Oil phase companions; enhance Ceramide NP dispersion in lipid matrix
✓
Sodium Hyaluronate, D-Panthenol — Full barrier repair ecosystem; address different repair layers simultaneously
✓
Niacinamide — Stimulates endogenous ceramide synthesis; synergistic with exogenous Ceramide NP supplementation
✓
Alpha-Bisabolol, Allantoin — Anti-inflammatory pairing; supports barrier repair in sensitive or reactive skin formulas
✓
Matrixyl 3000, Pro-Xylane — Anti-aging peptides complement ceramide barrier work; add peptides in cool-down phase
⚠ Use with Caution
⚠
High-concentration surfactants — Strong detergents can disrupt the lamellar structure Ceramide NP is building; keep surfactant levels low in leave-on products
⚠
High-load AHAs / BHAs — Exfoliant systems are mechanistically opposed to barrier repair; use in separate product lines or with lower acid concentrations
✗ Incompatible
✗
Pure water phase addition — Ceramide NP is not water-soluble; adding to aqueous phase without proper emulsifier system causes visible precipitation and failed emulsion
✗
Processing below melting point without solubiliser — Ceramide NP melts at ~80°C; incomplete dissolution results in white specks and uneven active distribution
Packaging & Supply
Pack size
Custom — as required
MOQ
Contact for quote
Sample available
Yes · 5 g
Appearance
White waxy solid
Melting point
~80°C
Storage
Cool, dry, sealed
Shelf life
24 months (sealed)
HPLC purity
≥ 98% · Batch certified
Pro Tip · Solubilisation
If formulating a water-based serum, use a ceramide pre-dispersion or solubiliser system (e.g. PEG-40 Hydrogenated Castor Oil) at a 4:1 ratio to Ceramide NP before adding to the aqueous phase. This prevents precipitation and ensures even distribution without requiring an oil phase.
Contact our team for aqueous ceramide formulation protocols →
Ceramide NP Technical Support Hub
Expert answers for formulators and procurement managers.
1. What are the specific temperature and solvent requirements for complete dissolution?
Ceramide NP is a high-purity crystalline lipid with a high melting point (approx. 90-105°C). It must be added to the oil phase and heated to at least 90°C. We recommend using polar oils like Caprylic/Capric Triglyceride (MCT) or Isopropyl Myristate as solvents. Adding a small amount of lecithin or phytosterols can significantly lower the recrystallization temperature.
2. Why is the "Molar Ratio" so important in barrier repair formulations?
Clinical studies show that the skin's lipid barrier consists of Ceramides, Cholesterol, and Free Fatty Acids. Using Ceramide NP alone is effective, but using a 3:1:1 molar ratio mimics the natural lamellar structure of the stratum corneum, accelerating barrier recovery by up to 40% compared to single-ingredient formulas.
3. How can I prevent the finished cream from becoming "grainy" over time?
"Graininess" is usually caused by Ceramide recrystallization. This occurs if the cooling process is too rapid or the oil phase cannot hold the lipid. Ensure slow, controlled cooling and maintain a final formulation pH between 5.0 and 7.0. Using a high-shear homogenizer during the emulsification stage is also critical.
4. Is Ceramide NP suitable for post-procedure (laser/peel) skincare?
Absolutely. Ceramide NP is bio-identical and non-irritating. It is highly recommended for medical-grade "repair" products. It helps reduce erythema (redness) and trans-epidermal water loss (TEWL) in compromised skin, making it a staple for clinical skincare lines.
5. Does Onerchem’s Ceramide NP comply with Vegan and Cruelty-free standards?
Yes. Our Ceramide NP is produced via a high-tech fermentation process using yeast, making it 100% plant-derived/vegan. It is non-GMO, BSE/TSE free, and has not been tested on animals, meeting all major global clean beauty standards (Ecocert/COSMOS compliant).
Formulation Support Available
This ingredient is a core component of our Whitening Application Solutions.
In-depth Technical Comparison
Alpha Arbutin vs. Niacinamide: Which one fits your formula best?
Additional information
| Technical Group | |
|---|---|
| Solution | , |
| Technical Keywords |
Sensitive Skin ,Barrier Repair ,Hydration |
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Shipping and Delivery
Onerchem B2B
✈ Ships from China
Shipping &
Delivery
All orders ship from our facility in mainland China. Samples are dispatched within 7 working days. Bulk orders follow a confirmed production schedule — with full documentation in every parcel.
≤7
Days · Sample dispatch
15–40
Days · Bulk lead time
Global
EU · GCC · ASEAN · NA
COA
Included every shipment
Dispatch Timeline
When does my order ship?
Dispatch timelines differ between sample and bulk orders. A confirmed dispatch date is always provided at order confirmation.
Sample Orders
≤7 working days
From order confirmation to dispatch
Samples are QC-checked, weighed, and packed individually. Your COA and MSDS are printed and included in the parcel before sealing. Most sample orders ship ahead of the 7-day window.
Tracking number provided on dispatch · Express courier available on request
Bulk Orders
15–40 working days
Varies by quantity and specification
Lead time is determined by order volume, packaging format, and whether custom labelling or documentation is required. A production and dispatch schedule is confirmed in writing at the time of order.
Schedule confirmed at order · Progress updates available on request
Process
From order to delivery
Four steps from confirmed order to goods in hand.
01
Order Confirmed
Written confirmation sent within 1 business day. Dispatch schedule and freight quote included for bulk orders.
02
QC & Packing
Batch is QC-checked against HPLC data. COA and MSDS are generated and packed with the shipment.
03
Dispatch
Shipment handed to carrier. Tracking number and commercial invoice sent to buyer by email on the same day.
04
Delivery
Goods arrive at destination. 7 working-day inspection window begins from the confirmed delivery date.
Transit Times by Region
Estimated time in transit
Transit estimates run from dispatch date and exclude customs clearance time, which varies by country and commodity.
| Region | Est. Transit | Notes |
|---|---|---|
| EU & UK | 7–14 days | Import duties and VAT assessed at customs — payable by buyer. REACH compliance documentation available on request. |
| GCC / Middle East | 5–10 days | Customs clearance handled by buyer or nominated freight agent. Certificate of Origin available on request. |
| ASEAN | 4–8 days | Country-specific import licences or permits may apply for certain actives. Buyer is responsible for pre-shipment compliance checks. |
| North America | 7–14 days | FDA Prior Notice may be required for cosmetic actives. Buyers are advised to confirm import classification before ordering. |
| Other Regions | 10–20 days | Contact us to confirm shipping availability and any documentation requirements specific to your country. |
All transit times are estimates only · Delays may occur due to customs inspection, public holidays, or carrier disruption
Freight & Documentation
Costs and paperwork
Freight is quoted individually based on weight, destination, and Incoterm. Full shipping documentation is prepared for every order.
Freight Policy
—Freight cost quoted at order confirmation
—Rates based on gross weight, destination, and selected Incoterm
—Express courier (DHL / FedEx / UPS) available on request
—Sea freight available for larger bulk orders
—Import duties and local taxes are the buyer's responsibility
Documents Included
✓Commercial Invoice
✓Packing List
✓Certificate of Analysis (batch-specific)
✓MSDS / Safety Data Sheet
✓Certificate of Origin — on request
Need a freight quote or shipping advice?
Email us with your destination, estimated order weight, and preferred Incoterm — we'll respond within 1 business day.
Global shipping
EU · GCC · ASEAN · Americas
Samples ≤7 working days
From order confirmation
Full documentation
COA · MSDS · Invoice · Packing list
Tamper-evident packing
UV-protected, sealed containers
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