Ergothioneine (EGT) Powder CAS 497-30-3
Buy high-purity L-Ergothioneine (EGT) from Onerchem. Bio-fermented active for superior mitochondrial protection and anti-aging. 99% HPLC purity with full COA/MSDS. Global delivery.
›How to Choose an Ergothioneine Supplier for Cosmetics | Onerchem
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Description
Super Antioxidant · Cellular Longevity · Sensitive Skin
Ergothioneine
CAS 497-30-3 · L-Ergothioneine · EGT
≥98%
HPLC Purity
Recommended Dose
0.1 – 1.0%
0.5% as standard efficacy level
Optimal pH
4.0 – 8.0
Exceptionally broad — pH stable
Solubility
Water soluble
Aqueous phase — easy incorporation
Addition Phase
Water or cool-down
Heat stable up to 80°C
Market Trend · 2024–2026
Ergothioneine is the fastest-growing antioxidant in premium skincare — and supply is still limited
Search interest for Ergothioneine in cosmetics has grown significantly year-on-year since 2022, driven by dermatologist endorsement and clinical publications on its longevity-linked properties. It remains a differentiated ingredient with limited competitive presence — brands formulating with EGT now are ahead of the curve on a category that is gaining mainstream momentum.
Why Ergothioneine
1
The only antioxidant with its own dedicated cellular transporter
Human skin cells express OCTN1 — a specific transporter protein evolved to actively accumulate ergothioneine from the environment. This is not passive diffusion. It is selective biological uptake, suggesting ergothioneine plays an irreplaceable role in cellular antioxidant defence that the body has specifically evolved to prioritise. No other common cosmetic antioxidant has this mechanism.
2
Outperforms glutathione and Vitamin C in oxidative stress protection
Published comparative studies show ergothioneine is significantly more effective than glutathione and L-Ascorbic Acid at quenching hydroxyl radicals — the most reactive and damaging free radical species in UV-exposed skin. Its thiol group provides antioxidant activity across a uniquely broad range of reactive oxygen species, including singlet oxygen, peroxynitrite, and metal-catalysed oxidants.
3
Anti-inflammaging and DNA protection in one active
Beyond antioxidant activity, ergothioneine inhibits the nuclear factor NF-κB inflammatory pathway — reducing chronic low-level inflammation that drives skin aging independently of UV damage. It also demonstrates DNA protection against oxidative strand breaks, supporting the emerging category of "longevity" skincare claims that are distinct from conventional anti-aging positioning.
Mechanism of Action
Multi-Target Activity
Three mechanisms that work simultaneously — not sequentially
Mechanism 1
Broad-Spectrum Radical Quenching
The thiohistidine structure of ergothioneine allows it to neutralise a wider range of reactive oxygen and nitrogen species than conventional antioxidants — including hydroxyl radical, singlet oxygen, peroxynitrite, and hypochlorous acid. This breadth is what justifies "super antioxidant" positioning in consumer communications.
Mechanism 2
NF-κB Inflammaging Inhibition
Ergothioneine suppresses the NF-κB signalling pathway — a master regulator of inflammatory gene expression. By reducing this chronic inflammatory background, it addresses inflammaging at a signalling level, distinct from and complementary to anti-inflammatory actives like Niacinamide or Panthenol.
Mechanism 3
OCTN1 Transporter Accumulation
Skin cells actively import and accumulate ergothioneine via the OCTN1 transporter — building an intracellular reservoir that provides sustained protection long after topical application. This active accumulation explains why ergothioneine's cellular protection persists beyond what passive diffusion-based antioxidants can achieve.
Formulation Parameters
Key Parameters
Dosage range0.1% – 1.0%
Optimal pH4.0 – 8.0 (very broad)
SolubilityWater soluble
Heat stabilityStable to 80°C
AppearanceWhite crystalline powder
HPLC purity≥ 98% · Batch certified
Formulation Advantages
Incorporation easeExcellent — dissolves in water
pH flexibilityWorks in serums AND creams
Colour / odourColourless, odourless in formula
Heat processingCan go into Phase A at 70–75°C
Sensitive skinNo known irritation risk
TrendingFast-growing category 2024–26
Ingredient Compatibility
✓ Synergistic
✓CoQ10 — Complementary antioxidant mechanisms: Ergo (aqueous/cellular) + CoQ10 (lipid membrane); together cover full oxidative stress spectrum
✓Ferulic Acid + 3-O-EAA — Multi-layer antioxidant stack; Ergo adds cellular accumulation that topical antioxidants alone cannot achieve
✓Niacinamide, Ceramides, Panthenol — Full sensitive skin + antioxidant formula; excellent compatibility across all skin types
✓ Compatible
✓Matrixyl 3000, GHK-Cu — No interaction; add in respective phases as normal
✓Tranexamic Acid, Alpha-Arbutin — Brightening stack partner; antioxidant support reduces oxidative PIH triggers
✓Retinol (separate product) — Ergo's anti-inflammatory properties support skin during retinol's retinization period; ideal for AM/PM pairing
⚠ Note
⚠No known incompatibilities — Ergothioneine's exceptional stability and neutral chemistry make it one of the most formulation-friendly actives available
Target Applications
Longevity & "Skin Health" Serums
The emerging longevity skincare category — positioned beyond conventional anti-aging. Ergo's OCTN1 transporter mechanism and DNA protection properties support credible "cellular longevity" claims.
Premium Antioxidant Formulas
Pairs with CoQ10, Ferulic Acid, and Vitamin C derivatives for a complete multi-layer antioxidant system addressing membrane, aqueous, and cellular compartments simultaneously.
Sensitive Skin Collections
No known irritation risk, broad pH tolerance, and potent anti-inflammatory activity make Ergo the ideal antioxidant for reactive, rosacea-prone, or compromised skin formulas.
Post-Procedure Recovery
NF-κB suppression reduces post-procedure inflammation; antioxidant activity protects compromised skin from oxidative damage during the recovery window after laser or chemical peel.
Brightening Formulas
Reduces oxidative stress at inflammation sites that trigger PIH. Complements TXA and Alpha-Arbutin in a comprehensive brightening stack by addressing the upstream oxidative component of melanocyte activation.
Men's Skincare
The "super antioxidant" narrative resonates with male consumers who respond to efficacy-first positioning. Ergo's invisible, odourless formulation profile suits the minimalist textures preferred in men's skincare.
Supplier Information · Onerchem
Sourcing Ergothioneine from Onerchem
Every batch HPLC-verified to ≥98% purity. Batch-specific COA and MSDS issued with each order. Ergothioneine supply is limited industry-wide — contact us early to confirm availability and lead time for your production schedule.
Supply Details
Pack sizeCustom — as required
MOQContact for quote
SampleYes · 1 g available
AvailabilityContact — limited supply
Quality & Documentation
Purity≥ 98% HPLC verified
COABatch-specific, every order
MSDSAvailable on request
Pre-order COAAvailable — email request
Storage & Logistics
StorageCool, dry, sealed
Shelf life24 months sealed
Ships fromMainland China
MarketsEU · GCC · ASEAN · North America
HPLC Purity ≥98%
Batch-Specific COA
EU Cosmetics Compliant
REACH Documentation
GCC / ASEAN Compatible
7-Day Inspection Window
Response within 1 business day
Pre-order COA available
Custom pack sizes
7-day quality inspection window
Replacement or full refund
Technical FAQ
Reviews (0)
Shipping and Delivery
Onerchem B2B
✈ Ships from China
Shipping &
Delivery
All orders ship from our facility in mainland China. Samples are dispatched within 7 working days. Bulk orders follow a confirmed production schedule — with full documentation in every parcel.
≤7
Days · Sample dispatch
15–40
Days · Bulk lead time
Global
EU · GCC · ASEAN · NA
COA
Included every shipment
Dispatch Timeline
When does my order ship?
Dispatch timelines differ between sample and bulk orders. A confirmed dispatch date is always provided at order confirmation.
Sample Orders
≤7 working days
From order confirmation to dispatch
Samples are QC-checked, weighed, and packed individually. Your COA and MSDS are printed and included in the parcel before sealing. Most sample orders ship ahead of the 7-day window.
Tracking number provided on dispatch · Express courier available on request
Bulk Orders
15–40 working days
Varies by quantity and specification
Lead time is determined by order volume, packaging format, and whether custom labelling or documentation is required. A production and dispatch schedule is confirmed in writing at the time of order.
Schedule confirmed at order · Progress updates available on request
Process
From order to delivery
Four steps from confirmed order to goods in hand.
01
Order Confirmed
Written confirmation sent within 1 business day. Dispatch schedule and freight quote included for bulk orders.
02
QC & Packing
Batch is QC-checked against HPLC data. COA and MSDS are generated and packed with the shipment.
03
Dispatch
Shipment handed to carrier. Tracking number and commercial invoice sent to buyer by email on the same day.
04
Delivery
Goods arrive at destination. 7 working-day inspection window begins from the confirmed delivery date.
Transit Times by Region
Estimated time in transit
Transit estimates run from dispatch date and exclude customs clearance time, which varies by country and commodity.
| Region | Est. Transit | Notes |
|---|---|---|
| EU & UK | 7–14 days | Import duties and VAT assessed at customs — payable by buyer. REACH compliance documentation available on request. |
| GCC / Middle East | 5–10 days | Customs clearance handled by buyer or nominated freight agent. Certificate of Origin available on request. |
| ASEAN | 4–8 days | Country-specific import licences or permits may apply for certain actives. Buyer is responsible for pre-shipment compliance checks. |
| North America | 7–14 days | FDA Prior Notice may be required for cosmetic actives. Buyers are advised to confirm import classification before ordering. |
| Other Regions | 10–20 days | Contact us to confirm shipping availability and any documentation requirements specific to your country. |
All transit times are estimates only · Delays may occur due to customs inspection, public holidays, or carrier disruption
Freight & Documentation
Costs and paperwork
Freight is quoted individually based on weight, destination, and Incoterm. Full shipping documentation is prepared for every order.
Freight Policy
—Freight cost quoted at order confirmation
—Rates based on gross weight, destination, and selected Incoterm
—Express courier (DHL / FedEx / UPS) available on request
—Sea freight available for larger bulk orders
—Import duties and local taxes are the buyer's responsibility
Documents Included
✓Commercial Invoice
✓Packing List
✓Certificate of Analysis (batch-specific)
✓MSDS / Safety Data Sheet
✓Certificate of Origin — on request
Need a freight quote or shipping advice?
Email us with your destination, estimated order weight, and preferred Incoterm — we'll respond within 1 business day.
Global shipping
EU · GCC · ASEAN · Americas
Samples ≤7 working days
From order confirmation
Full documentation
COA · MSDS · Invoice · Packing list
Tamper-evident packing
UV-protected, sealed containers
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