Ascorbyl Palmitate | CAS 137-66-0 | Oil-Soluble Vitamin C | Onerchem
High-purity Ascorbyl Palmitate (CAS 137-66-0) from Onerchem. A stable, lipid-soluble form of Vitamin C for superior skin penetration and oil-phase protection.
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Description
Oil-Soluble Vitamin C · Antioxidant · Lipid Preservation
Ascorbyl Palmitate
CAS 137-66-6 · L-Ascorbyl 6-palmitate · Vitamin C palmitate
≥98%
HPLC Purity
Recommended Dose
0.1 – 1.0%
0.3–0.5% for standard antioxidant
Solubility
Oil phase only
Lipophilic — requires oil or ester carrier
Optimal pH
3.5 – 5.5
Best stability in acidic systems
Addition Phase
Oil phase < 60°C
Dissolve in carrier oil before processing
Where Ascorbyl Palmitate fits — vs water-soluble VC derivatives
✓ Ascorbyl Palmitate
The oil-phase Vitamin C
Dissolves in oils, esters, and lipid phases — no aqueous system needed
Protects lipid components from oxidative rancidity — extends formula shelf life
Stable in anhydrous systems indefinitely — no water to accelerate degradation
Ideal for oil serums, balms, W/O emulsions, and lipid-rich night creams
VS
3-O-EAA / AA2G
Water-phase derivatives
Require aqueous phase — cannot be used in anhydrous systems
Do not protect oil phase components from lipid peroxidation
pH management needed — susceptible to aqueous-phase degradation over time
Better choice for direct brightening effect in aqueous serums
Ascorbyl Palmitate and aqueous VC derivatives are not competing actives — they address different phases of the same formula. Using both (AP in the oil phase + 3-O-EAA in the aqueous phase) provides complete antioxidant coverage across all formula compartments.
Why Ascorbyl Palmitate
1
Protects the oil phase — a role no water-soluble VC can fill
Oxidative rancidity in lipid-rich formulas begins in the oil phase, where unsaturated fatty acids are most vulnerable to free radical chain reactions. Ascorbyl Palmitate, being lipophilic, positions itself precisely in this phase and quenches radicals before lipid peroxidation cascades can develop. This extends the sensory shelf life and odour stability of oils, emollients, and wax-based formulas that aqueous antioxidants cannot protect.
2
Enables Vitamin C activity in anhydrous and low-water systems
Oil serums, facial oils, balms, and W/O emulsions cannot use water-soluble VC derivatives without compromising their formulation architecture. Ascorbyl Palmitate is the only practical way to incorporate Vitamin C antioxidant activity into these product formats — which are growing rapidly as a category, particularly in premium facial oil and luxury balm segments.
3
Both an antioxidant and a cosmetic preservative booster
Ascorbyl Palmitate is approved as both a cosmetic active and a food-grade antioxidant (E304). At 0.02–0.1%, it functions as an antioxidant preservative booster in formulas using natural or semi-natural oil systems — extending the oxidative stability of hemp, rosehip, marula, and other PUFA-rich carrier oils that would otherwise require synthetic antioxidants like BHT.
Mechanism of Action
Lipophilic Antioxidant
Three functions — active, protective, and preservative
Function 1
Lipid Peroxidation Chain-Breaking
The ascorbyl group donates hydrogen atoms to interrupt the lipid peroxidation radical chain reaction in the oil phase. By quenching lipid peroxy radicals, it prevents the cascade that converts healthy unsaturated fatty acids into rancid degradation products — protecting both the formula and any carrier oils against oxidative breakdown.
Function 2
Vitamin C Activity in Skin Lipids
After absorption, esterases in skin hydrolyse Ascorbyl Palmitate to free ascorbic acid and palmitic acid. The released ascorbic acid enters the aqueous compartments of skin cells, providing collagen synthesis support and antioxidant activity — delivering VC bioactivity from an entirely lipophilic carrier that bypasses the penetration barriers that limit water-soluble derivatives.
Function 3
Tocopherol Regeneration
Like other Vitamin C forms, Ascorbyl Palmitate participates in the tocopherol regeneration cycle — reducing oxidised Vitamin E back to its active form, extending the antioxidant protection of the oil phase beyond what either active alone provides. This synergy is most valuable in high-PUFA carrier oil systems where oxidative pressure is greatest.
Formulation Parameters
Key Parameters
Cosmetic dose (active)0.1% – 1.0%
Preservative booster dose0.02% – 0.1%
Optimal pH3.5 – 5.5
SolubilityOil / ester / wax (lipophilic)
Melting point107–117°C
HPLC purity≥ 98% · Batch certified
Incorporation Notes
Carrier recommendationSqualane, Caprylic/Capric Triglyceride
Dissolution temp50–60°C in carrier oil
Addition timingOil phase — before emulsification
PackagingOpaque / UV-protective preferred
SynergyTocopherol 0.5–1.0% strongly recommended
Appearance in formulaColourless at standard doses
Ingredient Compatibility
✓ Recommended Combinations
✓Tocopherol (Vitamin E) — Essential synergy partner; mutual regeneration extends both actives' efficacy in the oil phase
✓Ferulic Acid — Full antioxidant regeneration trio when combined with Tocopherol; sacrificial protection for both
✓Squalane, Jojoba, plant esters — Ideal carrier oils; AP disperses evenly and provides protection for these emollients
✓Ceramide NP — AP protects Ceramide NP from oxidative degradation in the oil phase — a useful formulation synergy
✓ Compatible
✓3-O-EAA, AA2G (aqueous phase) — Complementary VC coverage: AP in oil phase + water-soluble VC in aqueous phase = complete antioxidant system
✓CoQ10 — Both lipophilic antioxidants; combined oil phase antioxidant protection across multiple mechanisms
⚠ Note
⚠pH above 6.5 — AP stability decreases in neutral-to-alkaline systems; keep formulas below pH 6.0 for best shelf life
⚠High water activity — In high-water-activity emulsions, ester hydrolysis can occur over time; pair with Tocopherol to buffer oxidative consequences
Target Applications
Facial & Body Oils
The primary Vitamin C option for pure oil products. Provides antioxidant activity and protects the carrier oil blend from oxidative rancidity — extending both efficacy and sensory shelf life.
Oil-Rich Night Creams
High-lipid emulsions benefit disproportionately from oil-phase antioxidants. AP at 0.3–0.5% alongside Tocopherol is the standard antioxidant system for luxury oil-heavy formulas.
Natural & Clean Beauty
Food-grade antioxidant status (E304) allows "natural preservative" positioning. Enables brands to avoid synthetic antioxidants like BHA/BHT in natural carrier oil systems.
Anhydrous Balms & Sticks
The only Vitamin C form that works in wax-based, solvent-free formats. Protects lip balms, body balms, and solid cosmetics from oxidative degradation without any water-phase requirement.
Sunscreen Formulas
AP in the oil phase complements UV filters by scavenging the residual oxidative damage that UV radiation causes beyond the SPF protection limit — a meaningful photoaging prevention claim.
Hair Oils & Treatments
Protects both the carrier oil system and hair lipids from oxidative damage. Useful in argan oil, keratin treatment, and scalp serum formulas where lipid integrity affects hair health claims.
Supplier Information · Onerchem
Sourcing Ascorbyl Palmitate from Onerchem
Every batch HPLC-verified to ≥98% purity. Batch-specific COA and MSDS issued with each order. Custom pack sizes available — contact us for MOQ and current lead time.
Supply Details
Pack sizeCustom — as required
MOQContact for quote
SampleYes · 10 g available
Lead timeContact for current schedule
Quality & Documentation
Purity≥ 98% HPLC verified
COABatch-specific, every order
MSDSAvailable on request
Pre-order COAAvailable — email request
Storage & Logistics
StorageCool, dry, away from light
Shelf life24 months sealed
Ships fromMainland China
MarketsEU · GCC · ASEAN · North America
HPLC Purity ≥98%
Batch-Specific COA
EU Cosmetics Compliant
Food-Grade Antioxidant (E304)
GCC / ASEAN Compatible
7-Day Inspection Window
Response within 1 business day
Pre-order COA available
Custom pack sizes
7-day quality inspection window
Technical FAQ
Reviews (0)
Shipping and Delivery
Onerchem B2B
✈ Ships from China
Shipping &
Delivery
All orders ship from our facility in mainland China. Samples are dispatched within 7 working days. Bulk orders follow a confirmed production schedule — with full documentation in every parcel.
≤7
Days · Sample dispatch
15–40
Days · Bulk lead time
Global
EU · GCC · ASEAN · NA
COA
Included every shipment
Dispatch Timeline
When does my order ship?
Dispatch timelines differ between sample and bulk orders. A confirmed dispatch date is always provided at order confirmation.
Sample Orders
≤7 working days
From order confirmation to dispatch
Samples are QC-checked, weighed, and packed individually. Your COA and MSDS are printed and included in the parcel before sealing. Most sample orders ship ahead of the 7-day window.
Tracking number provided on dispatch · Express courier available on request
Bulk Orders
15–40 working days
Varies by quantity and specification
Lead time is determined by order volume, packaging format, and whether custom labelling or documentation is required. A production and dispatch schedule is confirmed in writing at the time of order.
Schedule confirmed at order · Progress updates available on request
Process
From order to delivery
Four steps from confirmed order to goods in hand.
01
Order Confirmed
Written confirmation sent within 1 business day. Dispatch schedule and freight quote included for bulk orders.
02
QC & Packing
Batch is QC-checked against HPLC data. COA and MSDS are generated and packed with the shipment.
03
Dispatch
Shipment handed to carrier. Tracking number and commercial invoice sent to buyer by email on the same day.
04
Delivery
Goods arrive at destination. 7 working-day inspection window begins from the confirmed delivery date.
Transit Times by Region
Estimated time in transit
Transit estimates run from dispatch date and exclude customs clearance time, which varies by country and commodity.
| Region | Est. Transit | Notes |
|---|---|---|
| EU & UK | 7–14 days | Import duties and VAT assessed at customs — payable by buyer. REACH compliance documentation available on request. |
| GCC / Middle East | 5–10 days | Customs clearance handled by buyer or nominated freight agent. Certificate of Origin available on request. |
| ASEAN | 4–8 days | Country-specific import licences or permits may apply for certain actives. Buyer is responsible for pre-shipment compliance checks. |
| North America | 7–14 days | FDA Prior Notice may be required for cosmetic actives. Buyers are advised to confirm import classification before ordering. |
| Other Regions | 10–20 days | Contact us to confirm shipping availability and any documentation requirements specific to your country. |
All transit times are estimates only · Delays may occur due to customs inspection, public holidays, or carrier disruption
Freight & Documentation
Costs and paperwork
Freight is quoted individually based on weight, destination, and Incoterm. Full shipping documentation is prepared for every order.
Freight Policy
—Freight cost quoted at order confirmation
—Rates based on gross weight, destination, and selected Incoterm
—Express courier (DHL / FedEx / UPS) available on request
—Sea freight available for larger bulk orders
—Import duties and local taxes are the buyer's responsibility
Documents Included
✓Commercial Invoice
✓Packing List
✓Certificate of Analysis (batch-specific)
✓MSDS / Safety Data Sheet
✓Certificate of Origin — on request
Need a freight quote or shipping advice?
Email us with your destination, estimated order weight, and preferred Incoterm — we'll respond within 1 business day.
Global shipping
EU · GCC · ASEAN · Americas
Samples ≤7 working days
From order confirmation
Full documentation
COA · MSDS · Invoice · Packing list
Tamper-evident packing
UV-protected, sealed containers
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